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ORIGINAL ARTICLE
Year : 2015  |  Volume : 2  |  Issue : 2  |  Page : 113-117

Consanguinity and clefts in the craniofacial region: A retrospective case-control study


1 Department of Anatomy, Vydehi Institute of Medical Sciences and Research Centre, Bengaluru, Karnataka, India
2 Department of Plastic Surgery, Vydehi Institute of Medical Sciences and Research Centre, Bengaluru, Karnataka, India
3 Department of Statistician, Vydehi Institute of Medical Sciences and Research Centre, Bengaluru, Karnataka, India

Correspondence Address:
Asst prof. Betty Anna Jose
Department of Anatomy, Vydehi Institute of Medical Sciences and Research Centre, Bengaluru - 560 066, Karnataka
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/2348-2125.162965

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Objective: The objective was to investigate the association between consanguinity and clefts in the craniofacial region. Materials and Methods: Sample consists of 179 non-syndromic cases of clefts in the craniofacial region and 200 healthy controls with no cleft or family history of clefting. A standardized questionnaire was prepared to investigate the information on the demographic characteristics and consanguinity. Chi-square and odds ratio were used to evaluate the risk of consanguinity in clefts in the craniofacial region. Results: There is a significant association between consanguinity and clefts (P = 0.001) when comparing the consanguinity and no consanguinity in cleft group and non-cleft group, and the association is more with the second degree consanguinity than the third degree consanguinity. Conclusion: Consanguinity is a risk factor for clefts in the craniofacial region.


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